Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response
نویسندگان
چکیده
منابع مشابه
Human Plasma Alpha 2-macroglobulin
Activation of plasma kallikrein arginine esterase activity by kaolin resulted in peak activity at 1 min of incubation and a 50% reduction in activity at 5 min in normal plasma, and 30% reduction in the plasma of patients with hereditary angioneurotic edema who lacked the C1 inactivator. The peak esterolytic activity was inhibited by soybean trypsin inhibitor whereas the 5 min activity was resis...
متن کاملAlpha-2-Macroglobulin: A Physiological Guardian
Alpha macroglobulins are large glycoproteins which are present in the body fluids of both invertebrates and vertebrates. Alpha-2macroglobulin (a2M), a key member of alpha macroglobulin superfamily, is a high-molecular weight homotetrameric glycoprotein. a2Mhasmany diversified and complex functions, but it is primarily known by its ability to inhibit a broad spectrumof proteaseswithout the direc...
متن کاملAlpha 2 macroglobulin state in acute pancreatitis. Raised values of alpha 2 macroglobulin-protease complexes in severe and mild attacks.
Plasma values of C reactive protein, alpha 1 proteinase inhibitor, alpha 2 macroglobulin, and complexed alpha 2 macroglobulin have been determined in serial samples from 27 patients with acute pancreatitis. Complexed alpha 2 macroglobulin was measured by a novel enzyme linked immunosorbent assay with a monoclonal antibody specific for the complexed form. Patients with severe illness had lower c...
متن کاملLocal and systemic innate immune response to secondary human peritonitis
INTRODUCTION Our aim was to describe inflammatory cytokines response in the peritoneum and plasma of patients with peritonitis. We also tested the hypothesis that scenarios associated with worse outcome would result in different cytokine release patterns. Therefore, we compared cytokine responses according to the occurrence of septic shock, mortality, type of peritonitis and peritoneal microbio...
متن کاملDifferential expression of alpha 2 macroglobulin in response to dietylstilbestrol and in ovarian carcinomas in chickens
BACKGROUND Alpha 2 macroglobulin (A2M; also known as ovostatin), a homotetrameric protein with four disulfide-linked subunits, has the unique feature of inactivating/inhibiting most known proteases including serine-, threonine-, cysteine-, aspartic- and metalloproteases. In chickens, A2M has been identified and characterized biochemically, but little is known of its functional role(s) in the ov...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2015
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2015.09.021